Lipid nanoparticle delivery of siRNA targeting Cyp2e1 gene attenuates subacute alcoholic liver injury in mice.

Shuang Wu,Qiubing Chen,Yalan Wang,Hao Yin,Yuan Wei

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences（2023）

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摘要

The si-Cyp2e1 LNP may attenuate subacute alcoholic liver injury in mice mainly by reducing reactive oxygen levels, increasing antioxidant activity, blocking oxidative stress pathways and reducing ethanol-induced steatosis and inflammation.

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