Two new amides from Physochlainae Radix.

In this article, two undescribed amides (1-2) with an unusual (2-formyl-5- hydroxymethyl)-pyrroyl-butylamine moiety were obtained from the Physochlainae Radix. Comprehensive spectroscopic studies, including NMR and HRESIMS, coupling with spectroscopic data comparisons were used to determine structures. Anti-inflammatory assay results showed that new amides possessed significant inhibitory activities of the NO production of LPS-induced RAW 264.7 cells, with IC50 values of 17.52 ± 1.68 μM and 20.37 ± 2.42 μM, respectively.