Long-term use of mepolizumab in a case of chronic eosinophilic pneumonia: extending interval dosing.
The Journal of asthma : official journal of the Association for the Care of Asthma(2023)
摘要
INTRODUCTION:Mepolizumab, a humanized anti IL-5 monoclonal antibody, has been used off-label for chronic eosinophilic pneumonia (CEP), inducing disease remission and saving systemic corticosteroids.
CASE STUDY:We present a case of CEP, requiring long-term corticosteroids therapy due to relapse upon withdrawal. Mepolizumab was started and maintained for 2 years and 6 months.
RESULTS:Corticosteroids could be withdrawn and mepolizumab dose interval was spared up to 10 wk with no disease relapse.
CONCLUSION:Mepolizumab is shown to be useful for chronic eosinophilic pneumonia, allowing corticosteroid withdrawal. Dose interval may be individualized under close monitoring, for a more efficient treatment, reducing medical costs while improving patients' quality of life.
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