Intersection of Diverse Neuronal Genomes and Neuropsychiatric Disease: the Brain Somatic Mosaicism Network

Michael J. McConnell,John V. Moran,Alexej Abyzov,Schahram Akbarian,Taejeong Bae,Isidro Cortes-Ciriano,Jennifer A. Erwin,Liana Fasching,Diane A. Flasch,Donald Freed,Javier Ganz,Andrew E. Jaffe,Kenneth Y. Kwan,Minseok Kwon,Michael A. Lodato,Ryan E. Mills,Apua C. M. Paquola,Rachel E. Rodin,Chaggai Rosenbluh,Nenad Sestan,Maxwell A. Sherman,Joo Heon Shin,Saera Song,Richard E. Straub,Jeremy Thorpe,Daniel R. Weinberger,Alexander E. Urban,Bo Zhou,Fred H. Gage,Thomas Lehner,Geetha Senthil,Christopher A. Walsh,Andrew Chess,Eric Courchesne,Joseph G. Gleeson,Jeffrey M. Kidd,Peter J. Park,Jonathan Pevsner,Flora M. Vaccarino, Alison R. Barton, Stefan Bekiranov, Craig L. Bohrson, Ian E. Burbulis, William Chronister, Gianfilippo Coppola, Kenneth Daily, Alissa M. D’Gama, Sarah B. Emery, Trenton J. Frisbie, Tianliuyun Gao, Attila Gulyás-Kovács, Mark Haakenson, Jason M. Keil, Huira C. Kopera, Mandy M. Lam, Eunjung Alice Lee, Tomas Marques-Bonet, Gary W. Mathern, John B. Moldovan, Matthew T. Oetjens, Larsson Omberg, Mette A. Peters, Sirisha Pochareddy, Tiziano Pramparo, Aakrosh Ratan, Tiziana Sanavia, Lei Shi, Mario Skarica, Jia Wang, Meiyan Wang, Yifan Wang, Margaret Wierman, Matthew Wolpert, Mollie Woodworth, Xuefang Zhao, Weichen Zhou

Science（2017）

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Abstract

Single-cell diversity in the brain The cells that make up an organism may all start from one genome, but somatic mutations mean that somewhere along the line of development, an organism's individual cellular genomes diverge. McConnell et al. review the implications and causes of single-cell genomic diversity for brain function. Somatic mutations caused by mobile genetic elements or errors in DNA repair may underlie certain neuropsychiatric disorders. Science , this issue p. eaal1641

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