Effects of desmopressin plus propiverine for the treatment of monosymptomatic primary nocturnal enuresis in children

You have accessJournal of UrologyCME1 Apr 2023PD06-09 EFFECTS OF DESMOPRESSIN PLUS PROPIVERINE FOR THE TREATMENT OF MONOSYMPTOMATIC PRIMARY NOCTURNAL ENURESIS IN CHILDREN Do Gyeong Lim, Jeong Hoon Oh, Jiwon Ryu, Seong Hyeon Yu, Ho Seok Chung, Eu Chang Hwang, Kyung Jin Oh, Seung Il Jung, Taek Won Kang, Kwangsung Park, Dong Deuk Kwon, and Sun-Ouck Kim Do Gyeong LimDo Gyeong Lim More articles by this author , Jeong Hoon OhJeong Hoon Oh More articles by this author , Jiwon RyuJiwon Ryu More articles by this author , Seong Hyeon YuSeong Hyeon Yu More articles by this author , Ho Seok ChungHo Seok Chung More articles by this author , Eu Chang HwangEu Chang Hwang More articles by this author , Kyung Jin OhKyung Jin Oh More articles by this author , Seung Il JungSeung Il Jung More articles by this author , Taek Won KangTaek Won Kang More articles by this author , Kwangsung ParkKwangsung Park More articles by this author , Dong Deuk KwonDong Deuk Kwon More articles by this author , and Sun-Ouck KimSun-Ouck Kim More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003230.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We evaluated the efficacy of a combination treatment of desmopressin and propiverine for treating children with monosymptomatic primary nocturnal enuresis. METHODS: A total of 53 children aged 6 to 15 years old with monosymptomatic nocturnal enuresis prospectively were enrolled in this study. Children with a minimum of 3 wet nights weekly were included in the study. Children were randomly assigned groups and treated with desmopressin 0.2mg, or a combination of desmopressin plus propiverine 10mg. Of these patients 43 (31 boys and 12 girls, mean age 8.4±2.5 years, range 4 to 13) were followed for more than 6 months. Efficacy was measured at 1, 3 and 6 months in terms of average enuretic frequency after treatment. RESULTS: Of the 43 children finally analysed 23 received combination therapy of desmopressin and propiverine and 20 received desmopressin alone. The frequency of nocturnal enuresis at baseline in monotherapy group and combination therapy was similar (5.45±1.57 vs 5.82±1.44). However, decrease of the nocturnal enuresis was significantly pronounced in combination group after 6 months treatment than in monotherpy group (1.8±1.01 vs 1.29±0.67). Combination therapy produced better outcomes than monotherapy in terms of number of nocturnal enuresis episode. The adverse event was minimal. CONCLUSIONS: Combination therapy with desmopressin plus propiverine for the treatment of monosymptomatic nocturnal enuresis was well tolerated, and gave significantly effective results in reducing enuresis episode than single therapy of desmopressin in children. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e159 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Do Gyeong Lim More articles by this author Jeong Hoon Oh More articles by this author Jiwon Ryu More articles by this author Seong Hyeon Yu More articles by this author Ho Seok Chung More articles by this author Eu Chang Hwang More articles by this author Kyung Jin Oh More articles by this author Seung Il Jung More articles by this author Taek Won Kang More articles by this author Kwangsung Park More articles by this author Dong Deuk Kwon More articles by this author Sun-Ouck Kim More articles by this author Expand All Advertisement PDF downloadLoading ...