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TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.

Li Zhong,Xuan Sheng,Wanbing Wang,Yanzhong Li,Rengong Zhuo,Kai Wang,Lianshuai Zhang,Dan-Dan Hu,Yujuan Hong, Linting Chen, Hengjun Rao,Tingting Li, Muyang Chen,Zhihao Lin,Yun-Wu Zhang,Xin Wang,Xiao-Xin Yan,Xiaochun Chen,Guojun Bu,Xiao-Fen Chen

Immunity（2023）

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关键词
neurodegeneration,Alzheimer’s disease,TREM2,C1q,C3,complement,synaptic loss,microglia
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