18β-Glycyrrhetinic Acid Alleviates P. multocida -Induced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells.

Qirong Lu,Wantong Han,Defeng Wen,Pu Guo,Yu Liu,Zhongyuan Wu,Shulin Fu,Chun Ye,Xu Wang,Yinsheng Qiu

Infection and drug resistance（2023）

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摘要

These findings, for the first time, demonstrate the potential therapeutic relationship among GA, PARP1 and inflammatory injury, providing a candidate drug, therapeutic targets and explanation for treating vascular endothelial inflammatory injury caused by infection.

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关键词

hmgb1 signalling suppression,inflammation,piec cells,multocida-induced

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