Two-Year Outcomes of Treatment-Experienced Adults after Programmatic Transitioning to Dolutegravir: Longitudinal Data from the VICONEL Human Immunodeficiency Virus Cohort in Lesotho.
Clinical infectious diseases/Clinical infectious diseases (Online University of Chicago Press)(2023)
摘要
In the Viral Load Cohort North-East Lesotho (VICONEL) human immunodeficiency virus cohort, 14 242 adults had transitioned from efavirenz- or nevirapine-based antiretroviral therapy (ART) to dolutegravir-based ART by October 2021. Rates of viral suppression to <50 copies/mL were 84.8%, 93.9%, and 95.4% before, 12 months after, and 24 months after transition, respectively. Sex, age, pretransition viral load, and treatment backbone correlated with 24-month viremia.
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关键词
Africa,integrase inhibitors,treatment outcome,treatment failure,observational study
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