Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.
Mu A,Thomas E Wales,Haixia Zhou,Sorin-Valeriu Draga-Coletă,Christoph Gorgulla,Katherine A Blackmore,Melanie J Mittenbühler,Caroline R Kim,Dina Bogoslavski, Qiuyang Zhang,Zi-Fu Wang,Mark P Jedrychowski,Hyuk-Soo Seo,Kijun Song,Andrew Z Xu,Luke Sebastian,Steven P Gygi,Haribabu Arthanari,Sirano Dhe-Paganon,Patrick R Griffin,John R Engen,Bruce M Spiegelman Molecular cell（2023）
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