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Enhancing Anti-Aml Activity of Venetoclax by Isoflavone ME-344 Through Suppression of OXPHOS And/or Purine Biosynthesis in Vitro

Katie H. Hurrish,Yongwei Su,Shraddha Patel,Cassandra L. Ramage,Jianlei Zhao, Brianna R. Temby,Jenna L. Carter,Holly Edwards,Steven A. Buck,Sandra E. Wiley,Maik Huttemann,Lisa Polin,Juiwanna Kushner,Sijana H. Dzinic,Kathryn White,Xun Bao,Jing Li,Jay Yang,Julie Boerner,Zhanjun Hou,Gheath Al-Atrash,Sergej N. Konoplev,Jonathan Busquets,Stefano Tiziani,Larry H. Matherly,Jeffrey W. Taub,Marina Konopleva,Yubin Ge,Natalia Baran

BIOCHEMICAL PHARMACOLOGY（2024）

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Key words
Acute myeloid leukemia,ME-344,Oxidative phosphorylation,Purine biosynthesis,Venetoclax
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