In Situ Supramolecular Self-Assembly for Alleviating Multidrug Resistance in Cancer
Supramolecular Materials（2023）
aSchool of Materials Science and Engineering | bCAS Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety
Abstract
Drug resistance is one of the major causes of cancer treatment failures. In recent years, to combat the issue of drug resistance, a large volume of strategies has been established along the development of biomedical nanomaterials. Compared with traditional nanocarrier-based drug delivery strategies, in situ supramolecular self-assembly has emerged as a promising strategy to overcome drug resistance. This review first introduced the concept of in situ supramolecular self-assembly. The second part illustrated the mechanisms of constructing in situ supramolecular self-assembly as a multi-step process. The third part elucidated the role of in situ supramolecular self-assembly to reverse drug resistance, which included three categories: active self-assembly materials, drug-carrier self-assembly materials and drug-coupled self-assembly materials. At last, we summarized the current development of in situ supramolecular self-assembly for the reversal of drug resistance and the remaining concerns to be addressed.
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Key words
In situ supramolecular self-assembly,Nanomaterials,Enzyme,Multidrug resistance,Cancer
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