A novel dual-plasmid platform provides scalable transfection yielding improved productivity and packaging across multiple AAV serotypes and genomes

Laura P. van Lieshout,Miranda Rubin, Katrina Costa-Grant,Stacy Ota,Diane Golebiowski, Troy Panico, Eli Wiberg,Klaudia Szymczak,Richard Gilmore,Marissa Stanvick,Brenda Burnham,Jeff Gagnon, Ifeyinwa Iwuchukwu, Guang Yang, Iraj Ghazi, Alex Meola,Ryan Dickerson, Thomas Thiers, Luke Mustich,April Hayes, Israel Rivas, Jason Lotterhand, Nancy Avila, James McGivney, Jin Yin, Tim Kelly

Molecular therapy Methods & clinical development（2023）

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关键词

AAV,AAV manufacturing,transient transfection,dual-plasmid system,VG productivity,vector quality

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