Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis

Hye Jin Chun,Eun Ran Kim,Minyoung Lee,Da Hyun Choi,Soo Hyun Kim,Eugene Shin,Jin-Hong Kim,Jin Won Cho,Dai Hoon Han,Bong-Soo Cha,Yong-ho Lee

Metabolism（2023）

引用 1|浏览9

暂无评分

摘要

•SGLT2 expression and O-GlcNAcylation was increased in human NASH liver.•SGLT2 expression correlated with the degree of hepatic fibrosis in humans.•Upregulation of SGLT2 increased O-GlcNAcylation in hepatocytes under NASH condition.•SGLT2 inhibition improved NASH phenotypes via modulating O-GlcNAcylation and AMPK.•Reduced O-GlcNAc by SGLT2 inhibition enhanced AMPK-TFEB mediated autophagic flux.

查看译文

关键词

Non-alcoholic steatohepatitis, Sodium-glucose transport protein 2, O-linked N-acetylglucosamine, Autophagy, Diabetes

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要