CD1d-dependent natural killer T-cells inactivation aggravates sepsis-induced myocardial injury via T lymphocytes infiltration and IL-6 production in mice

Li-Rui Chen, Hui-Yang, Lu-Liu,Xiao-Xiao Wang, Xiao-Man Zhang,Hong-Xia Wang

International Immunopharmacology（2023）

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摘要

•NKT cells number and CD1d expression were both increased in hearts and blood in WT mice after LPS treatment.•CD1dko accelerated LPS induced sepsis-induced-cardiomyopathy (SIC).•These effects were partially associated with accumulation of T lymphocytes and the up-regulation of IL-6 protein levels.

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关键词

Sepsis-induced cardiomyopathy,CD1d-dependent natural killer T cells,Endothelial dysfunction,Myocardial edema,T lymphocytes,IL-6

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