Photothermal enhanced polyphenol-based nanofibers ameliorate catalytic efficiency of ferroptosis for synergistic tumor therapy
Chemical Engineering Journal(2023)
摘要
•Nanofibrous iron-polyphenol-aspirin-coordinated nanochelates (GAFs) were constructed by inventive introduction of aspirin.•The variations in size and structure allowed the GAFs to avoid the risk of premature renal clearance in vivo.•The GAFs with slender nanofibrous morphology possessed superior Fenton catalytic activity and photothermal performance.•The GAFs could inhibit COX-2/PGE2, in combination with photothermal-enhanced ferroptosis tumor therapy to induce ICD.•This work provided a novel avenue to potentiate the synergistic NIR absorbing Fenton catalytic performance.
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关键词
Fe (II)-polyphenol nanochelates, Ferroptosis, Photothermal effect, Cyclooxygenase-2, Activation of antitumor immune response
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