Rescue of proteotoxic stress and neurodegeneration by the Zn 2+ transporter ZIP7.

Xiaoran Guo, Morgan Mutch,Alba Yurani Torres,Maddalena Nano,Drew McDonald,Zijing Chen,Craig Montell,Wei Dai,Denise J Montell

bioRxiv : the preprint server for biology（2023）

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摘要

Zn transport from the ER to the cytosol promotes deubiquitination and proteasomal degradation of misfolded proteins and prevents blindness in a fly neurodegeneration model.

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