Chronic Inflammation on Prostate Needle Biopsy as a Significant Predictor of the Lower Incidence Risk of Prostate Cancer

Abstract Purpose: At present, there is no clear relationship between prostatitis and prostate cancer(PCa). Therefore, in order to further understand the inflammation of prostate tissue and the occurrence of PCa, we conducted this study.Method: A total of 686 patients were enrolled in the study. All patients underwent prostate biopsy in our hospital. A retrospective analysis of the biopsy results was performed to assess the assocition between chronic inflammation and the risk of PCa.Result: Of the 686 patients, 354 were diagnosed with PCa, and 332 were benign. A total of 403 patients had prostate inflammation. PCa patients had lower prostate volume and transition zone volume than benign group(p＜0.001). Compared with benign group, PCa patients had lower PSA and PSA density (PSAD)(p＜0.001). We also found that the probability of inflammation in PCa patients is lower than that in the benign group (p＜0.001). In multivariate analyses, chronic inflammation was negatively correlated with the incidence of PCa（OR=0.80; p=0.015). Conclusion: Chronic inflammation in biopsy tissue might serve as a predicted factor for low incidence risk of PCa.