Creutzfeldt-Jakob disease with neuroleptic malignant syndrome

Creutzfeldt – Jakob disease (CJD) is a rare neurodegenerative disease with complex clinical manifestations. Neuroleptic malignant syndrome (NMS) is a complication of antipsychotic medications which are used to treat neuropsychiatric symptoms of CJD. We present a case of a 51-year-old woman with CJD who developed NMS after being prescribed quetiapine.