Synthesis of Trifunctional Thiazole-Fused Anthranilonitrile and Anthranilic Acid Derivatives
SYNTHESIS-STUTTGART(2023)
摘要
The synthesis of trifunctional isomeric benzothiazoles derived from nitroanthranilic acids and their corresponding anthranilonitrile analogues is studied. Compared to previous work, the reaction sequence affords convenient access to hitherto undescribed 2-cyanobenzothiazoles. For further synthetic applications of these poly-functional compounds, a hydrolysis-decarboxylation sequence is per -formed in an acidic medium (HCl or HBr), leading to an enlarged array of relevant building blocks.
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关键词
N-arylcyanothioformamides,4,5-dichloro-1,2,3-dithiazoli-um chloride,N-arylimino-1,2,3-dithiazoles,2-cyanobenzothiazoles,an-thranilic acid,anthranilonitrile,intramolecular C-S bond formation,decyanation
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