ANTINEOPLASTIC ACTIVITY OF EXTRACTS OF THE ANTARCTIC YEAST SPOROBOLOMYCES ROSEUS AL103 ON URINARY BLADDER CANCER CELLS

Currently, malignant diseases are one of the leading causes of mortality worldwide. Antarctic yeasts represent a poorly explored source of novel bioactive compounds with antineoplastic activity and expected favourable toxicological profile. The aim of the work was the evaluation of the antiproliferative and proapoptotic potential of extracts obtained from the psychrophilic strain Sporobolomyces roseus AL103. Data from MTT dye reduction assay showed that urothelial cancer cell line T-24 was more sensitive (85--101 μg/mL) than the non-tumour cell line (CCL-1- 343 to 432 μg/mL). Apoptosis analysis after treatment with different yeast extracts revealed strong potential to inhibit various antiapoptotic factors as well as selective induction of apoptosis in tumour cells as confirmed by flow cytometry, too.