Design of High-Sensitivity Surface Plasmon Resonance Sensor Based on Nanostructured Thin Films for Effective Detection of DNA Hybridization

Abstract With the increasing ability to control infectious diseases in developed countries, there has come the realization that genetic diseases are a major cause of disability, death, and human tragedy. Recently, Coronavirus as an epidemic, has spread worldwide and the ability to identify low concentrations and the mutations of the virus can effectively reduce the spread of the disease. In this paper, A surface plasmon resonance sensor based on nanostructured thin films and graphene as a 2D material has been designed with high sensitivity and accuracy to identify DNAbased infectious diseases such as SARS-CoV-2. The effects of different structural factors, including nanolayers thickness on the sensor’s performance are assessed through the transfer matrix method. The results demonstrated that the sensor with the Kretschmann configuration has ultra-high sensitivity (192.19 deg/RIU) and a high figure of merit (634.68 RIU -1 ).