MR-Spectroscopy: Investigating Neurochemical Changes in Brain Metabolism in Migraineurs Before and after CGRP-Antibody Treatment – a Randomized, Controlled, Open-Label Trial

Background Imaging techniques have revealed important aspects of the underlying pathophysiological mechanisms of migraine, suggesting abnormal energy metabolism and increased cerebral hyperexcitability as triggers for a migraine attack. Since only a small percentage of monoclonal CGRP antibodies crosses the blood-brain barrier, their main site of action outside the blood-brain barrier is discussed. It is uncertain whether they lead to central effects through their action outside the blood-brain barrier or exert direct central effects.