Immune Restoring CAR-T Cells Display Antitumor Activity and Reverse Immunosuppressive TME in a Humanized Ccrcc Mouse Model

Yufei Wang,Jae-Won Cho,Gabriella Kastrunes,Alicia Buck,Cecile Razimbaud,Aedin C. Culhane,Jiusong Sun,David A. Braun,Toni K. Choueiri,Catherine J. Wu,Kristen Jones,Quang-De Nguyen, Zhu,Kevin Wei, Quan Zhu,Sabina Signoretti,Gordon J. Freeman,Martin Hemberg,Wayne A. Marasco

ISCIENCE（2024）

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关键词

Chimeric antigen receptor (CAR) T,immune restoring (IR),clear cell renal cell carcinoma (ccRCC),carbonic anhydrase IX (CAIX),single cell RNA sequencing (scRNAseq)

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