Resuscitation fluids for patients with risk factors of multiple organ failure: A systematic review and meta-analysis

Review question / Objective: P: patients with risk factors of multiple organ failure I: balanced crystalloids C: normal saline O: mortality, in-hospital mortality, renal failure, length of ICU stay, length of hospital stay. Condition being studied: In clinical field, aggressive fluid resuscitation therapy is administered to prevent the progression of multiple organ failures by maintaining tissue and organ perfusion. Normal saline is frequently used, but it has been some concerns. Although large-scale studies with balanced crystalloids have been conducted, they couldn’t reach significant conclusions due to the diversity of disease severity. Therefore, we aims to evaluate and identify the best fluid for patients at high risk of multiple organ failure by comparing the effects of normal saline and balanced crystalloids.