Cerebral redistribution in late-onset fetal growth restriction: not always the same story (Winner of the SIMP EUBRAIN Award, in memory of J. Claudine Larroche for the study on PVL in 1962)

Objective.To evaluate perinatal outcomes of late-onset FGR fetuses showing cerebral redistribution in relation to modifications of Doppler components of cerebroplacental ratio (CPR).Materials and Methods.Multicentre retrospective study including non-anomalous singleton pregnancies complicated by late-onset FGR featuring CPR < 5° P. Perinatal outcomes were compared across four subgroups: 1. fetuses showing UAPI < 95° P and MCAPI > 5° P; 2. UAPI > 95° P and MCAPI > 5° P; 3. UAPI < 95° P and MCAPI < 5° P; 4. UAPI > 95° P and MCAPI < 5° P. Results.308 cases were included: 33.4% belonged to group 1, 28.8% group 2, 20.5% group 3, 17.2% group 4. Group 2 was associated with lower gestational age at delivery (37+0+2+1 vs 38+0+1+6, 37+5+1+6 and 37+5+1+6 weeks for groups 1,