Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

A Concise Approach for the Synthesis of the Tetracyclic Framework of Lycibarbarines A and B

Manoj N. Shet, Hemanth K. Nechooli,Chepuri V. Ramana

Tetrahedron Letters（2023）

Cited 2|Views4
No score
Abstract
A simple approach for the construction of the tetracyclic spiroketal skeleton of Lycibarbarine A and B has been described. Employing a solvent free condition for epoxide opening with tetrahydroquinoline as a key reaction to couple both the fragments, an oxidation followed by TBAF-mediated silyl deprotection spiroketalization establishes the complete tetracyclic core present in these natural products. (c) 2023 Elsevier Ltd. All rights reserved.
More
Translated text
Key words
Total synthesis,Tetracyclic spiroketal,Chiral pool approach,D -Glyceraldehyde
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined