Failing Categorization of Severe COVID-19 ARDS into Ventilatory Subphenotypes Studied Via the Clinical-Histopathologic Relationship

•Respiratory system compliance at ICU admission is not different between survivors and non-survivors.•Prevailing fibroproliferation is associated to more time spent in ICU and low respiratory system compliance during ICU stay.•Histopathological patterns and lung mechanoelastic characteristics evolve during disease course in critically ill patients.•Timeless categorization into low and high Crs phenotypes does not account for the mechanoelastic ventilatory trajectories.