Properties and pharmacokinetics of FFC/amphiphilic chitosan derivatives nano-micelles

Florfenicol (FFC) is a novel form of specific antibiotic for animals, but because of its low water solubility, it has a lot of challenges in veterinary therapeutic use. A new form of amphiphilic chitosan derivative nano-material—HPCH-SA nano-micelle—was produced in this research to address the problem of FFC's poor water solubility. TEM was used to examine the nano-micelles. Taking particle size, Zeta potential and critical micelle concentration (CMC) as evaluation criteria, the properties of FFC/HPCH-SA nano-micelles were studied by stability investigation. The pharmacokinetics of FFC/HPCH-SAnano-micelles was studied in SD rats by oral administration. The results showed that the FFC/HPCH-SA nano-micelles were spherical with a smooth surface and good distribution. The particle size was 246.13±2.99 nm, the electric potential was 32.4±1.92 mV. Florfenicol must be stored in a dry location. In rats, FFC had a quick absorption rate, wide distribution, moderate elimination rate, and long half-life. It had a high oral bioavailability and could be kept in rats for a long time. This study found that an amphiphilic chitosan derivative nano-micelle, HPCH-SA, might efficiently increase the water solubility and bioavailability of hydrophobic medicines, and that it had a wide range of applications.