Chorioamnionitis. Modern View of the Problem

Objective of the Review: To conduct a comprehensive analysis of the current state of the problem of obstetrics chorioamnionitis (HA). Key Points. HA leads to an increased risk of other obstetric complications. Newborns from mothers with HA are at high risk of neonatal sepsis, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, neonatal death. The authors tend to replace the term HA with a more general descriptive term: “intrauterine inflammation or infection, or both” (Triple I). To further clarify the definition and treatment of this complex group of conditions, a set of studies is needed. Conclusion. In recent years, there have been changes in opinion on some issues regarding the problem of HA. So, new terms were proposed, diagnostic criteria were clarified, at the same time, the main changes relate, first of all, to perinatal aspects, more precisely in the management of newborns from mothers with suspected intrauterine infection and from mothers with HA, to observe (rather than treat) those born in a satisfactory condition of full-term and late premature newborns. That is, investigators tend to favor a management strategy consisting of close observation of healthy full-term and late preterm infants suspected of having intrauterine infection, which they consider to be preferable to empiric antimicrobial therapy. Keywords: chorioamnionitis, intrauterine infection, infections of the amniotic cavity and fetal membranes.