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NEUROFILAMENT LIGHT CHAIN (NFL) AND GENERAL COGNITIVE ABILITY IN ADULTS APPROACHING MIDLIFE

INNOVATION IN AGING(2022)

Univ Calif Riverside | Univ Colorado Boulder

Cited 0|Views27
Abstract
Abstract Neurofilament light chain (NfL) is a biomarker indexing axonal integrity where small NfL variations may be associated with cognitive performance in early adulthood and high values associated with neurodegenerative disorders such as Alzheimer’s disease. In the Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife1) individuals were tested at 28–49 years (M=33.1, SD=4.9). Quanterix Simoa assays of plasma NfL (pNfL) were measured in duplicate, and we included values for 1159 individuals where 1098 had available general cognitive ability scores and sociodemographic covariates. Unadjusted NfL values were consistent with other studies of early-mid adulthood (M = 5.9, SD = 3.1, range = 1.14 – 40.1 pg/mL) and 6% showed values outside expected normal reference limits (>10 pg/mL). After adjusting for technical covariates and skew, higher natural log-transformed pNfL was associated with age (r = 0.27) and female sex (r = 0.07). Moreover, adjusting for sociodemographic covariates, higher pNfL was associated with lower general cognitive ability (GCA) (r = -.06), where associations were more pronounced above the mean pNfL value (r = -.08). Multi-level regression analyses suggested that GCA-NfL associations were modified by age, whereby the worse performance was observed at higher ages and pNfL values (p <= 0.03), accounting for sibling relatedness and sociodemographic covariates. We observed small negative associations of higher plasma NfL and lower cognitive performance, where associations may become magnified with increasing age in early- to mid-adulthood.
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要点】:该研究探讨了神经丝轻链(NfL)与成年人早期至中年阶段的一般认知能力之间的关系,发现NfL水平与认知能力呈负相关,且这种关联随着年龄的增长而增强。

方法】:研究采用Quanterix Simoa技术测量了1159名28-49岁参与者的血浆NfL(pNfL)水平,并使用多水平回归分析来评估pNfL与一般认知能力(GCA)之间的关系。

实验】:在Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife)项目中,对参与者的pNfL进行了测量,并收集了1098名参与者的GCA分数和人口统计学协变量数据。结果显示,调整技术协变量和偏斜后,pNfL水平与年龄和性别相关,且在调整社会人口学协变量后,pNfL水平与GCA呈负相关。多水平回归分析表明,这种关联随着年龄的增长而更加显著。