Imaging-Based Characterization of OA Endotypes Derived from Biochemical Markers - Data from the Observational Multicenter Approach Cohort

Purpose: APPROACH (Applied public-private research enabling osteoarthritis clinical headway) is a European, 5-centre, 2-year prospective follow-up cohort project that collected clinical, imaging, biomechanical, and biochemical parameters. APPROACH was designed to identify outcome measures that can characterize different OA phenotypes that may benefit most from personalized therapies. Patients with a high likelihood of joint space width loss and/or increased or sustained knee pain over the course of the study were included based on rankings that were produced by machine learning models.