Association Analysis of Polymorphic Variants in ALDH7A1, AOC1, PSAP, ADCYAP1 Genes Involved in the Histamine Metabolism with Asthma Development in Individuals from the Republic of Bashkortostan

The aim of this study was to assess the role of polymorphic variants of aldehyde dehydrogenase 7 family member A1 ALDH7A1 (rs13182402), amine oxidase copper containing 1 AOC1 (rs1049793), prosaposine PSAP (rs11000016), adenylate cyclase activating polypeptide 1 ADCYAP1 (rs2231187) genes involved in the histamine metabolism in asthma development in individuals from the Republic of Bashkortostan. The statistically significant association of rs2231187*AA genotype and rs2231187*A allele of the ADCYAP1 gene with asthma, rs2231187*A allele of the ADCYAP1 gene with disease manifestation in childhood, rs2231187*AA genotype of the ADCYAP1 gene and rs13182402*G allele of the ALDH7A1 gene with severe and moderate asthma was established in individuals of Bashkir ethnicity. The rs1049793*CC genotype and rs1049793*C allele of the AOC1 was associated with asthma in Russians. The results of this study are complementary to the previously published data regarding genetic aspects of asthma pathogenesis that suggest the involvement of ALDH7A1, ADCYAP1 and AOC1 gene polymorphisms in asthma development.