Design of a Flexible Enzyme‐less Glucose Sensor Based on Non‐woven Fabric and Fe‐Doped CuO Nanocomposite

Among various enzyme-free sensors, transition metals and their oxides have been used as suitable modifiers for the design of glucose electrochemical sensors due to their availability and low cost. In the present study, a flexible, enzyme-less, nonwoven fabric-based glucose sensor was developed. We synthesized the Fe-doped CuO (Fe/CuO) chemically and used it as a modifier to the carbon paste to achieve this. A working electrode was created by stabilizing the paste on a nonwoven fabric. The fabric used did not require any pre-preparation except cleaning. The synthesized Fe/CuO was characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), electrochemical impedance spectroscopy (EIS), diffuse reflectance spectroscopy (DRS), and X-ray diffraction (XRD). The electrochemical properties of the Fe/CuO nanocomposite on the textile electrode were investigated using cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy. In the proposed enzyme-free sensor, Fe/CuO catalyzed the oxidation of glucose on the electrode surface. The sensor has high sensitivity, a wide linear range (2.5x10(-3)-6.57 mM), a low detection limit (8.0x10(-4) mM), long-term stability, and good selectivity. Finally, the sensor was used to determine the amount of glucose in a human sweat sample.