SORS Performance of Sublayer Materials with Different Optical Properties under Diffuse Scattering Media

Over the past few years, the utilization of spatially offset Raman spectroscopy (SORS) has significantly evolved in its ability to analyze layered turbid materials non-invasively. It is well known that SORS can effectively detect the deeper layer in a high scattering media, and the performance characteristics of SORS have been extensively studied. However, to date, there is a lack of detailed studies of SORS to detect materials with different optical properties. This study aims to fill this gap by constructing a simple bilayer model, in which a target material with different optical properties was covered with a diffuse scattering barrier. By analyzing the Raman intensity from both superficial barriers and underlying target materials, we investigated the SORS performance to probe three typical optical materials with distinct optical properties: strong absorption, high transparency, and strong scattering. It was found that SORS technology can readily detect the samples of different properties under turbid surface coverings, and the typical optical property of the sublayer materials provided a specific SORS feature. Our study demonstrates the great potential of SORS technology for the non-invasive detection of subcutaneous component applications and provides a comprehensive understanding of the SORS characteristic of various materials.