PNPLA3 I148M Polymorphism Aggravate Metabolic Liver Disease under Long-term High Fat Diet

Christian Trautwein,Huan Su,Madhuri Haque,Svea Becker,Karolina Edlund,Julia Duda,Qingbi Wang,Johanna Reißing,Hanns-Ulrich Marschall, Candels, Mohamed,Wilhelm Sjöland,Till Strowig,Jörg Rahnenführer,Jan Hengstler,Maximilian Hatting

39 Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber Zeitschrift für Gastroenterologie（2023）

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摘要

Background Nonalcoholic fatty liver disease (NAFLD), a widespread disease, is associated with multiple genetic risk factors. The PNPLA3 I148M polymorphism of the phospholipase patatin-like phospholipid domain containing protein 3 (PNPLA3) has been shown to worsen disease progression during metabolic liver disease. Current PNPLA3 I148M knockin animals fail to recapitulate the human phenotype.

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