Does Cranial Radiotherapy Cause Endocrine And Metabolic Late Effects In Childhood Cancer Survivors? A Single-Centre Experience.

Rationale: Growth hormone deficiency (GHD) impairs growth and contributes to the development of Non-Alcoholic Fatty Liver Disease (NAFLD) and related dyslipidaemia. Cranial radiotherapy (CRT) has been related with hypothalamic-pituitary function impairment. Aim of this study was to investigate whether CRT is associated to late endocrine and metabolic effects in childhood cancer survivors (CCS) previously irradiated.