Supplemental Figures S1-S15 from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks

Figure S1. Experimental Figure Scheme. Figure S2. ChIP-Seq quality assessment for different samples and histone marks. Figure S3. Comparable ChIP-Seq and ChIP-qRT-PCR detection of histone enrichment for different histone marks near three reference genes. Figure S4. Comparable expression of reference genes. Figure S5. H3K9ac histone mark enrichment distribution near transcription start sites. Figure S6. H3K27ac histone mark enrichment distribution near transcription start sites. Figure S7. H3K9me3 histone mark enrichment distribution near transcription start sites. Figure S8. Correlation between tissue specific H3K9ac histone peak enrichment and expression of nearby genes. Figure S9. Correlation between tissue specific H3K9me3 histone peak enrichment and expression of nearby genes. Figure S10. Correlation between tissue specific H3K4me3 histone peak enrichment and expression of nearby genes for six study samples and two PDX-parental tissues. Figure S11. Correlation between tissue specific H3K27ac histone peak enrichment and expression of nearby genes for six study samples and two PDX-parental tissues. Figure S12. Correlation between tissue specific H3K9ac histone peak enrichment and expression of nearby genes for six study samples and two PDX-parental tissues. Figure S13. Correlation between tissue specific H3K9me3 histone peak enrichment and expression of nearby genes for six study samples and two PDX-parental tissues. Figure S14. Scheme for integration of ChIP-Seq Specific Histone Peaks with Expression Variation Analysis (EVA). Figure S15. Correlation of H3K27ac-enriched with genes differentially regulated in mesenchymal and classical HPV+ HNSCC subtypes.