Supplementary Figures S1-S7 from A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence

Disabling RB bypasses PML-induced senescence in normal human fibroblasts (S1); Cyclin-dependent kinase inhibitors p21 and p16INK4A cooperate with PML to inhibit cancer cell proliferation (S2); CDK inhibitors enhance PML-mediated growth arrest and senescence in tumor cell lines (S3); Gene Set Enrichment Analysis (GSEA) showing homology to our gene expression profiling (S4); Gene Set Enrichment Analysis (GSEA) showing homology to our gene expression profiling (S5); Palbociclib or 5-Aza-dC sensitise cells to PML-induced irreversible growth arrest (S6); palbociclib decreased DNMT1 levels in a dose dependent manner (S7).