Supplementary Materials from Epigenetic Control of <i>Cdkn2a.Arf</i> Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion

Figure S1-7. Figure S1: Assessing the effect of EZH2i on in vitro T cell cytotoxic function. Figure S2: Systems approach uncovers drivers of T cell exhaustion resulting from EZH2-inhibtion. Figure S3: Loss of EZH2 function leads to metabolic exhaustion of T cells. Figure S4: Histone epigenetic landscape post EZH2 inhibition. Figure S5: EZH2 inhibition leads to histone epigenetic reprogramming. Figure S6: Arf contributes metabolic exhaustion independent of p53. Figure S7: Exogenous expression of EZH2Y641F in lymphocytes. Extended methods, table of key reagents and resources