Central Nervous System Disease in Primary Sjögren's Syndrome

Background Our aim was to study the clinico-radiological characteristics during the central neurological attack of Primary Gougerot-Sjögren syndrome (SS). Material(s) and Method(s) A retrospective study including patients with SS revealed by neurological disorders collected in the Neurology department of the military hospital between 2010 and 2021. All patients underwent cerebral and spinal magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis. Result(s) Twenty-one patients were included. The average age was 44 years old. A focal lesion was present in 62% of the cases made by a spinal cord syndrome (19%), a cerebrovascular accident (5%) and by epilepsy (5%). Diffuse damage was made up of cognitive disorders (4%). MRI showed demyelinating lesions in T2 and Flair hypersignal at the level of the supra and subtentorial floors (76%), and vascular lesions (5%). CSF analysis was normal in all patients. Conclusion(s) Central neurological involvement during SS is rarely described. We must think about it in the face of any unexplained neurological manifestation, especially in an inflammatory context or vasculitis lesions. Our aim was to study the clinico-radiological characteristics during the central neurological attack of Primary Gougerot-Sjögren syndrome (SS). A retrospective study including patients with SS revealed by neurological disorders collected in the Neurology department of the military hospital between 2010 and 2021. All patients underwent cerebral and spinal magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis. Twenty-one patients were included. The average age was 44 years old. A focal lesion was present in 62% of the cases made by a spinal cord syndrome (19%), a cerebrovascular accident (5%) and by epilepsy (5%). Diffuse damage was made up of cognitive disorders (4%). MRI showed demyelinating lesions in T2 and Flair hypersignal at the level of the supra and subtentorial floors (76%), and vascular lesions (5%). CSF analysis was normal in all patients. Central neurological involvement during SS is rarely described. We must think about it in the face of any unexplained neurological manifestation, especially in an inflammatory context or vasculitis lesions.