Supplementary Information from Enhanced Glycolysis Supports Cell Survival in EGFR-Mutant Lung Adenocarcinoma by Inhibiting Autophagy-Mediated EGFR Degradation

Supplementary information contains 8 supplementary figures. Supplementary Figure 1. EGFR knockdown decreases glycolytic gene expression at the transcription level. Supplementary Figure 2. Glucose deprivation renders EGFR-mutant NSCLCs more sensitive to cell growth and death. Supplementary Figure 3. EGFR-mediated enhanced glycolysis is an important TCA cycle fuel source. Supplementary Figure 4. Mitochondrial ATP production is necessary for EGFR stability. Supplementary Figure 5. Anisomycin treatment inhibits the EGFR signaling pathway and activates apoptosis via JNK activation in vivo. Supplementary Figure 6. JNK is a downstream target of ROS. Supplementary Figure 7. Activated autophagy induces apoptotic cell death in EGFR-mutant NSCLCs. Supplementary Figure 8. Glucose deprivation has minimal effect on the growth of EGFR-TKIs-resistant cell lines without EGFR dependency.