Supplementary Fig. 6 from Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models

Biodistribution of [18F]PARPi in healthy ntv-a;p53fl/fl mice 2 h p.i.. Animals were injected with [18F]PARPi 2 hours prior to the biodistribution study (n=4). To control for uptake specificity, one group (n=4) was injected with 1 mg Olaparib 30min prior to the [18F]PARPi injection. The biodistribution shows specific (=blockable) uptake of [18F]PARPi in several organs (e.g. lymph nodes, spleen, pancreas, bone, indicating the presence of PARP1 expressing cells, whereas the uptake in liver and kidney cannot be blocked and is therefore due to excretion processes. N=4 per group, 1 mg Olaparib 30 min prior for blocking. Bl-blood, Br-brain, SG-salivary gland, LN-lymph node, He-heart, Sp-spleen, Pa-pancreas, Li-liver, Ki-kidney, St-stomach, SI-small intestine, LI-large intestine, Mu-muscle, Bo-bone.