Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

    • Supplementary Methods, Figures 1-2 from Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis

    crossref（2023）

    Cited 0|Views32
    Abstract

    PDF file - 81K

    More
    Translated text
    求助PDF
    上传PDF
    View via Publisher
    Bibtex
    AI Read Science
    AI Summary
    AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.
    Example
    Background
    Key content
    Introduction
    Methods
    Results
    Related work
    Fund
    Key content
    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
    • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
    • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
    Upload PDF to Generate Summary
    Must-Reading Tree
    Example
    Generate MRT to find the research sequence of this paper
    Data Disclaimer
    The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
    Chat Paper
    【要点】：本文探讨了信号转导和转录激活因子3（STAT3）在致癌物诱导的肺癌发生过程中对抗肿瘤免疫的抑制角色，揭示了STAT3在肿瘤免疫逃逸中的关键作用。
    

    【方法】：作者通过分子生物学方法，包括基因敲除、免疫组化染色、流式细胞术等，研究了STAT3在肺肿瘤细胞和免疫细胞中的表达和功能。
    

    【实验】：实验在C57BL/6小鼠模型中进行，使用致癌物诱导肺癌，并利用STAT3基因敲除小鼠进行对比研究，发现STAT3的缺失显著增强了对肿瘤的免疫应答，数据集名称未在摘要中提及，但结果支持了STAT3在肺癌发展中的抑制性作用。