Supplementary Data from SMAD4 Loss Induces C-Myc–mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis

crossref(2023)

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Abstract
Supplementary Figures S1-5 S1: Effect of SMAD4 loss on intestinal stem cell, c-MYC, and NLE1 gene expression in CRC organoids S2: Effects of NLE1 ablation on growth and clonogenicity of CRC cell lines S3: Effects of NLE1 ablation on growth and clonogenicity of CRC PDTOs S4: Effects of NLE1 over-expression in human colonic epithelial cells and CRC organoids S5: NLE1 loss-mediated cell cycle arrest and apoptosis in HCT116 CRC cells and HCEC-1CT normal human colonic epithelial cells
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