Supplementary Figures from Mesenchymal CD44 Expression Contributes to the Acquisition of an Activated Fibroblast Phenotype via TWIST Activation in the Tumor Microenvironment

PDF file, 1638K, Transgenic bone marrow transplantation into GFP+ recipient mice resulted in mice with two labeled cell populations (S1); Fewer activated myofibroblast incorporation in tumors engrafted in CD44-/- BMT mice compared to WT BMT (S2); Human and murine MSC phenotype shows no difference between knockdown MSC and naive MSC (S3); Protein and RNA expression of CD44 ligands in tumor cell lines and MSC (S4); Blocking CD44 expression on MSC inhibits migration in vitro and in vivo (S5).