Aging Breaks Liver Vascular ‘zone Defense’
NATURE AGING(2023)
摘要
Wang Lin and his colleagues explore how aging reprograms spatially unique pathways in liver endothelial cells to cause fibrosis. They find that loss of KIT in liver endothelial cells close to the central vein upregulates the chemokine receptor CXCR4 to stimulate inflammation, enhance fibrosis and increase lipid accumulation in aged liver.
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关键词
Liver Regeneration
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