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TRPM8 indicates poor prognosis in colorectal cancer patients and its pharmacological targeting reduces tumour growth in mice by inhibiting Wnt/-catenin signalling

Ester Pagano,Barbara Romano,Donatella Cicia,Fabio A. Iannotti,Tommaso Venneri,Giuseppe Lucariello,Maria Francesca Nani,Fabio Cattaneo,Paola De Cicco,Maria D'Armiento,Marcello De Luca, Ruggiero Lionetti,Stefania Lama,Paola Stiuso,Pietro Zoppoli,Geppino Falco,Silvia Marchiano,Stefano Fiorucci,Raffaele Capasso,Vincenzo Di Marzo,Francesca Borrelli,Angelo A. Izzo

BRITISH JOURNAL OF PHARMACOLOGY（2023）

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Key words
colon cancer,pharmacology,transient receptor potential channels,TRPM8,Wnt/beta-catenin
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