Safety of Radiation Therapy in Patients with Prostate Cancer and Inflammatory Bowel Disease: A Systematic Review.

Prostate RT in patients with comorbid IBD appears to be associated with low rates of grade 3+ GI toxicity; however, the possibility of a higher risk of toxicity remains. Because certain higher-risk subpopulations were underrepresented, overgeneralization is cautioned against. Several strategies should be considered best practice to minimize the probability of toxicity in this susceptible population including careful patient selection, minimizing elective treatment volumes, utilizing rectal sparing techniques, and employing contemporary RT-advancements to minimize exposure to GI organs-at-risk (e.g., IMRT, MRI-based planning, image-guidance).