Attenuation of α-synuclein aggregation by catalytic photo-oxygenation.
Chemical communications (Cambridge, England)(2023)
摘要
We developed catalyst 11 to promote selective photo-oxygenation of α-synuclein amyloid and attenuate its aggregation. Catalyst 11 effectively oxygenated both small and large aggregates. The oxygenated α-synuclein exhibited lower seeding activity than intact α-synuclein. This study corroborates the feasibility of catalytic photo-oxygenation as an anti-synucleinopathy strategy.
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关键词
photo-oxygenation
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