Ginkgo Biloba Extract Attenuates Cisplatin-Induced Renal Interstitial Fibrosis by Inhibiting the Activation of Renal Fibroblasts Through Down-Regulating the HIF-1α/STAT3/IL-6 Pathway in Renal Tubular Epithelial Cells.

•The innovation of this study has the following two points. Firstly, we reported for the first time the relationship between the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells and the activation of renal fibroblasts into MFs. Secondly, EGb can effectively improve CDDP-induced RIF by down-regulating the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells and inhibiting the activation of renal fibroblasts into MFs.